منابع مشابه
Coagulation: consultative hemostasis.
Clinical hematologists are frequently consulted for the care of hospitalized patients with complicated coagulopathies. This chapter provides an update on the scientific and clinical advances noted in disseminated intravascular coagulation (DIC) and discusses the challenges in hemostasis consultation. In Section I, Dr. Marcel Levi reviews advances in our understanding of the pathogenic mechanism...
متن کاملTHROMBOSIS AND HEMOSTASIS Prothrombin activation in blood coagulation: the erythrocyte contribution to thrombin generation
Prothrombin activation can proceed through the intermediates meizothrombin or prethrombin-2. To assess the contributions that these 2 intermediates make to prothrombin activation in tissue factor (Tf)–activated blood, immunoassays were developed that measure the meizothrombin antithrombin (mTAT) and -thrombin antithrombin ( TAT) complexes. We determined that Tf-activated blood produced both TAT...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Mechanism of factor VIIa–dependent coagulation in hemophilia blood
The ability of factor VIIa to initiate thrombin generation and clot formation in blood from healthy donors, blood from patients with hemophilia A, and in anti–factor IX antibody–induced (“acquired”) hemophilia B blood was investigated. In normal blood, both factor VIIa–tissue factor (TF) complex and factor VIIa alone initiated thrombin generation. The efficiency of factor VIIa was about 0.0001 ...
متن کاملExperimental hemostasis in normal dogs and dogs with congenital disorders of blood coagulation.
By T. HovIG, H. C. RowsELL, W. J. DODDS, L. J#{216}RGENSEN AND J. F. NIUSTARD I NVESTIGATIONS of hemostasis and thrombosis in the microcirculation of animals during the past century have provided considerable insight into the mechanisms 69, 15, 16,30,33,51 63,64,66 The vessel wall, platelets and blood coagulation are recognized to be important. Hughes3’ considered that the speed with which plat...
متن کاملTHROMBOSIS AND HEMOSTASIS Systemic blood coagulation activation in acute coronary syndromes
We evaluated systemic alterations to the blood coagulation system that occur during a coronary thrombotic event. Peripheral blood coagulation in patients with acute coronary thrombosis was compared with that in people with stable coronary artery disease (CAD). Blood coagulation and platelet activation at the microvascular injury site were assessed using immunochemistry in 28 nonanticoagulated p...
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ژورنال
عنوان ژورنال: Science
سال: 1973
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.182.4107.87